Presents

From Neutron to Patient™

The Grand Opening of POINT Biopharma's Indianapolis Manufacturing Facility

Our Journey Began With An Idea

Joe McCann, Co-Founder and CEO:

The Power Of Precision

All common cancer treatments, such as chemotherapy, external beam radiotherapy and surgery, put a significant burden on both patients and their families. A new generation of radiopharmaceutical treatments are improving patient outcomes by precisely targeting tumors using ligands carrying radioisotopes. Lutetium-177 (Lu-177) has emerged as one of the radioisotopes of choice for the new generation of radiopharmaceutical treatments. Lu-177 does not appear naturally in nature; its production and usage is truly a remarkable feat.

The Creation of Lutetium-177

Extraction

Rare minerals are mined that contain trace amounts of Ytterbium, a metal with the symbol Yb on the periodic table. Pure Yb is then purified from the mineral ore.

Enrichment

The purified Yb is sent to a Calutron, a machine similar to a mass spectrometer, which further separates the purified Yb based on its mass. This process creates a stock of stable isotope Yb-176.

Activation

The Yb-176 is transported to a nuclear reactor, where it is irradiated. The addition of neutrons turns a small amount of the Yb-176 into a new isotope, Lutetium-177.

Shipment

Time is of the essence; the Lu-177 contained in the Yb-176 target has a half-life of only 6.6 days. It is therefore immediately transported to POINT's facility, where the Lu-177 will be purified, combined with the targeting ligand, and shipped to a treatment site for injection into the patient, all in ~4 days.

Innovative Cancer Treatments That Are Just-In-Time

Radiopharmaceuticals are sterile injectable radioactive products that are produced on-demand for a specific patient, presenting a unique set of manufacturing complexities.

Todd Hockemeyer, EVP U.S. Manufacturing:

Welcome To Our 80,000 ft² State-Of-The-Art Production Facility

The facility is licensed for alpha and beta emitting isotopes, and contains dedicated space for commercial-scale automated packaging. The current facility layout includes three clinical production suites, four isotope production suites, and three commercial production suites, with capacity for future expansion.
Location

Located at the Crossroads of America in Indianapolis, Indiana, shipments from the facility can reach 50% of the US population within 10 hours by local ground transportation, and to the rest of North America and Western Europe within 48 hours by air.

Production Clean Rooms

The large glass walls of the clean rooms serve a dual purpose – in addition to creating an open line of sight to all operations, they are also a key part of the ventilation systems, acting as transparent air ducts  to return air back to the HEPA filters.

Air Filtration and HVAC

Airflow and ventilation are key features of a GMP pharmaceutical manufacturing facility, especially when radioactive materials are handled. Over 160 HEPA fan filter units work in unison to supply ISO-certified rooms with incredibly low particulate airflow.

Microscopic, Cancer-Seeking Missiles

Radioligands are a type of radiopharmaceutical designed to precisely deliver radiation to tumors

Dr. Oliver Sartor, Tulane School of Medicine & Member of POINT Biopharma's Global Advisory Board:

If You Can See It, You Can Treat It

Radiopharmaceuticals targets can be used to deliver radioisotopes for diagnostic purposes as well as for therapeutic purposes, leading to the emergence of an exciting new field of medicine: theranostics

Diagnostic

First, a diagnostic scan using a camera that detects radioisotope emissions is performed on patients injected with the ligand carrying an imaging isotope such as Gallium-68 that targets a receptor in the tumor.

Therapeutic

The tumors illuminated in the imaging scan can be targeted using a similar ligand carrying a therapeutic isotope such as Lutetium-177, to deliver radiation directly to the tumor.

Jessica Jensen, EVP Clinical Development:

Radio­pharma­ceuticals Have A Bright Future Ahead

Pan-Tumor Targeting

New tissues agnostic ligands have the potential to exponentially increase the number of cancer indications treated by radioligands. An example of a tissue agnostic ligand is our PNT2004 program, which targets Fibroblast activation protein-α (or FAP-α). Found across a wide variety of tumors, targeting FAP-α with a radioligand could significantly increase that number of patients which could benefit from this breakthrough technology.

Improving On-Target Delivery

In addition to new targeting innovations, technologies to further increase the precision of radioligands are being developed by POINT, like our CanSEEK™ technology that prevents radioligands from binding to targets in healthy tissue, limiting accumulation of radioactivity in undesired locations.

Radioisotope Innovation

New radioisotopes like Actinium-225 and Astatine-211 are also beginning to enter clinical trials, each with a unique set of cancer fighting characteristics. More radioisotopes will enable new treatments, further improving patient outcomes.

A New Pillar of Oncology

Dr. Neil Fleshner, Chief Medical Officer:

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Forward Looking Statements
This promotional website contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. In some cases, you can identify forward-looking statements by the following words: “may,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “ongoing” or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. Although we believe that we have a reasonable basis for each forward-looking statement contained in this promotional website, we caution you that these statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. Forward-looking statements in this promotional website include, but are not limited to, statements regarding the benefits of the recently completed business combination, as well as statements about the potential attributes and benefits of POINT’s product candidates and the format and timing of POINT’s product development activities and clinical trials. We cannot assure you that the forward-looking statements in this promotional website will prove to be accurate. These forward-looking statements are subject to a number of significant risks and uncertainties that could cause actual results to differ materially from expected results, including, among others, the outcome of any legal proceedings that may be instituted against POINT following the closing of the business combination, the risk that the business combination disrupts current plans and operations, the ability to recognize the anticipated benefits of the business combination, which may be affected by, among other things, competition, the ability of POINT to grow and manage growth profitably and retain its key employees, the impact of COVID-19 on POINT’s business, the ability to maintain the listing of POINT’s common stock on the NASDAQ, changes in applicable laws or regulations, the possibility that POINT may be adversely affected by other economic, business, and/or competitive factors, and other risks and uncertainties, including those described in RACA’s definitive proxy statement filed with the SEC on June 9, 2021. Most of these factors are outside of POINT’s control and are difficult to predict. Furthermore, if the forward-looking statements prove to be inaccurate, the inaccuracy may be material. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by us or any other person that we will achieve our objectives and plans in any specified time frame, or at all. The forward-looking statements in this promotional website represent our views as of the date of this promotional website. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this promotional website.
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